Monday, May 19, 2014

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Gao Zhan natural science teaching boeing military aircraft resources platform is the prevention of malaria drug chloroquine (Chloroquine), America Erkui Ning (Mefloquine, Lariam), tetracycline (Doxycycline, Vibramycin), Atrovaquone / Proquanil (Malorone) and Primaquine (Palum ). Into the affected area before the start of the week to eat chloroquine once a week, oral 1000 mg, after leaving the affected areas need to continue to eat around. But above all regions of the parasite boeing military aircraft drugs have different resistance, or need advice beforehand physician.
In addition, for the treatment of tropical malaria artemisinin (artemisinin), was in 1969 to 1972, by a team led by Tu Yo Yo discovered and extracted artemisinin from Artemisia annua. Interestingly, there is a record of the use of Artemisia annua as early as 200 BC, for the treatment of skin diseases and other diseases, Tu Yo Yo team leader Mao Zedong's instructions at that time to find an appropriate antimalarial them from 2000 I kind of herbal prescription sorted out 640 kinds of antimalarial party set to mice as an animal model to detect the parasite over 200 parties boeing military aircraft and more than 380 herbal herbal extracts, which discovered artemisinin.
Malaria vaccine (called RTS, S vaccine) a potential of the world's GlaxoSmithKline Limited (GlaxoSmithKline, GSK) nearly 30 years of painstaking research results, philanthropist Bill Gates also tried to help the GSK vaccine development. RTS, S is a biological boeing military aircraft protein engineering, boeing military aircraft protein fragment of Plasmodium falciparum to hepatitis B virus binding protein, in order to intensify boeing military aircraft the human immune response. But in November 2012 published in the United States, "New England Journal of Medicine," the study reported that in African infants 6-12 weeks of age for clinical trial subjects, RTS, S vaccine effectiveness of only 31%, much lower than scientists expected, most of the vaccine efficiency of over 90% before considering the market, so this result allows developers and concerned sectors rather disappointing, GSK has invested $ 300 million for research and development, trial will last more than three years, needs to be done More work to determine where and how to use the RTS, S vaccine was likely to produce the greatest results.
August 2013 research report boeing military aircraft published in the scientific journal (Science), exposing the exciting news from Hosanna Rhea another biotech company (Sanaria Inc.) Leading malaria vaccine research program made new progress, Its launch PfSPZ vaccine 15 people in this small human trials, 12 were successful protection against malaria infection. This home is located in Maryland biotechnology company, its founder Hoffman decided in 2002 to a different conceptual design of malaria vaccines, he practiced with reference to the 1970s, a small human trials found that the parasite as a vaccine can have more than 90% effectiveness, the more complete immune response induced, can be successfully activated CD8 + T cells, clear the parasite Cryptosporidium was very important hepatocytes, the vaccine is made from a single boeing military aircraft protein can not reach such immunity.
PfSPZ vaccine irradiation weakened Plasmodium falciparum mainly to intravenously injected with a month to play a total administered 4, 6 out of 9 people from infection; another six subjects who applied is based on a slightly different boeing military aircraft way to play when administered 5, 6 which are given immunity. The next research goal will toward boeing military aircraft larger human trials, while observing the persistent boeing military aircraft protective vaccine, RTS mentioned earlier, S vaccine efficacy in about a year will gradually decline. On the other hand, we must test whether boeing military aircraft it can resist PfSPZ vaccine boeing military aircraft makes other kinds of violations of Plasmodium. As everyone boeing military aircraft expected PfSPZ vaccine, giving developers more kinetic energy, hoping boeing military aircraft to speed up human trials of the vaccine, the vaccine will be available as soon as possible, not only protect soldiers deeply infected with tourists, is one of the top ten causes of death in those malaria countries, this vaccine is even more precious.
References: Artemisinin: from herbal garden found http://www.cell.com/LaskerAward-Chinese Greenwood, B. & Owusu-Agyei, S. (2012) Malaria in the Post-Genome Era... Science, 338 (6103): 49-50 Kaiser, J. (2013) Unconventional vaccine shows promise against Malaria Science, 341 (6146):..... 605 Kappe, SHI & Mikolajczak, SA (2011) Another Shot at a Malaria Vaccine Science, boeing military aircraft 334 (6055):. 460-461 Malaria:. Total protection from malaria (2013) Nature Medicine, 19:... 1102 Scherf, A., Lopez-Rubio, JJ, Riviere, L. (2008) boeing military aircraft .... Antigenic variation in Plasmodium falciparum Annu Rev Microbiol, 62:.. 445-470 Vogel, G. (2012) Disappointing Results Blunt Hopes for Malaria Vaccine Science, 338 (6109):.. 871-872.
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